The Power of Prions: The Strange and Essential Proteins That Can Cause Alzheimer's, Parkinson's, and Other Diseases by Michel Brahic
- The Power of Prions: The Strange and Essential Proteins That Can Cause Alzheimer's, Parkinson's, and Other Diseases
- Michel Brahic
- Page: 192
- Format: pdf, ePub, mobi, fb2
- ISBN: 9780691252384
- Publisher: Princeton University Press
Download free e-book The Power of Prions: The Strange and Essential Proteins That Can Cause Alzheimer's, Parkinson's, and Other Diseases iBook (English literature) by Michel Brahic
The remarkable family of proteins that can make us very ill—but can also be linked to long-term memory, immunity, and the origin of life Over the last decade, scientists have discovered the importance and widespread presence in the body of a remarkable family of proteins known as prion proteins. Research links various types of prion proteins to neurodegenerative diseases such as Parkinson’s and Alzheimer’s—and this has fueled the search for new drugs that could halt the progression of these terrible disorders. Other discoveries have revealed the essential roles prion proteins play in memory and immunity, and—in an extraordinary finding—the part they may have played in the beginnings of life on our planet. In this engaging and accessible book, Michel Brahic tells the story of these amazing and versatile proteins. Brahic, a leading researcher on diseases of the central nervous system, first describes the discovery of prions and their role in infection, beginning with early work on the animal disease scrapie and a mysterious human illness in New Guinea, apparently transmitted by cannibalism. Prions were eventually identified and named by Stanley Prusiner in the 1980s. (Brahic tells us Prusiner’s alternate name for prion was “piaf.”) Prion proteins were then revealed as the cause of other illnesses, from “mad cow” disease and its human counterpart, Creutzfeldt-Jakob disease, to such noninfectious brain disorders as Parkinson’s and Alzheimer’s. While the prion proteins responsible for diseases are definitively “bad,” Brahic also explains that these abnormal prions are rare exceptions. Most of the time, prion proteins actually serve “good” and vital functions—and they may even have been present at the origin of life itself.
Structural Variations of Prions and Prion-like Proteins
prion-like proteins that make up neurodegenerative diseases (NDs), including Alzheimer's disease (AD) and Parkinson's disease (PD). Both amyloid-β (Aβ) and
The Power of Prions: The Strange and Essential Proteins
Research links various types of prion proteins to neurodegenerative diseases such as Parkinson's and Alzheimer's—and this has fueled the search for new drugs
The Power of Prions
Research links various types of prion proteins to neurodegenerative diseases such as Parkinson's and Alzheimer's—and this has fueled the search for new drugs
Dementia - Symptoms and causes
This rare brain disorder usually occurs in people without known risk factors. This condition might be due to deposits of infectious proteins called prions.
More Than 30 Years Since Their Discovery, Prions Still
“These distorted ('misfolded') proteins damage brain cells, leading to fatal dementias akin to human Alzheimer's and Parkinson's diseases.” When
New Insights Into the Pathogenesis of Alzheimer's Disease
The major pathological protein of AD, Aβ, has been shown to be an antimicrobial peptide, which surrounds invaders in the brain and forms plaques to protect the
The Power of Prions: The Strange and Essential Proteins
Research links various types of prion proteins to neurodegenerative diseases such as Parkinson's and Alzheimer's--and this has fueled the search for new drugs
Webinar: Pathogenic Protein Spread? Let's Think Again
In this manner, a growing number of scientists argue, Alzheimer's, Parkinson's, and frontotemporal dementias are similar to prion diseases such
Mad Cow And Alzheimer's Have Surprising Link
It turns out that both diseases involve something called a prion protein, a finding could one day lead to more effective treatments for
Alzheimer's Protein May Have Spread In Brain Tissue
Research on prion diseases in animals shows that drugs can help clear away the misfolded proteins that allow these diseases to progress, says
The Power of Prions by Michel Brahic
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